Inhibition of Foot-and-Mouth Disease Virus Replication by Hydro-alcoholic and Aqueous-Acetic Acid Extracts of Alhagi maurorum

antiviral activity of alhagi maurorum medik’s methanolic extract on foot and mouth disease virus (fmdv) in cell cultures

conclusions the present investigation supports the use of the methanolic extract of a. maurorum as an antiviral drug in folk and modern medicine. this activity may justify its use as a source of natural compounds to control fmdv in infected animals. background foot and mouth disease (fmd) is an infectious disease of cloven-hoofed animals that has adverse economic impacts. given the prevalence o...

Lyophilizing Foot-and Mouth Disease Virus at Low Drying Temperature

Foot-and-mouth Disease Virus Ribonucleic Acid

-The foot-and-mouth disease virus-RNA polymerase complex was released from membrane particulates present in the cytoplasm of infected baby hamster kidney cells. The soluble polymerase complex was fractionated by zonal centrifugation in sucrose gradients. Two polymerase complexes (RNA and protein complex) active in the cell-free system were isolated and had S-rate ranges of 20-70S and 100-300S, ...

Nucleotide mismatches of foot-and-mouth disease virus during replication.

As there is a lack of error correction mechanisms during RNA replication, foot-and-mouth disease virus (FMDV) has a very high mismatch rate, which leads to a high mutation rate, in the range of 10(-3) to 10(-5) per nucleotide site per genome replication. We examined the nucleotide mismatch of FMDV during replication, based on the whole genomes of the 7 serotypes retrieved from NCBI. With the Me...

pH Resistance of Foot-and-Mouth Disease Virus and its Complement-Fixing Antigen

Organic Circulation and persistence of Foot – and – Mouth disease virus type O in guinea pig

Since, the most susceptible laboratory animal to Foot–and–Mouth disease virus (FMDV) is guinea pig, and then one milliliter of FMDV type (O) concentrations of 106-106.5 TCID50was inoculated intradermally (ID) to 10 plantar surface of guinea pig (right side). Guinea pig adapted virus has been prepared after generalization phase, and then one milliliter of virus was inoculated intradermally to 30...